'A person’s baseline personality tends to predict how they will react to a psychedelic drug. Participants with naturally high openness scores are more likely to have positive, deeply meaningful experiences during a psychedelic trip...'
'“Data is difficult to interpret, because there are several study designs, and maybe some people already have different personality traits at baseline that could already be related to hallucinogen use,” dos Santos said.'
Classic psychedelics linked to lasting increases in openness and drops in neuroticism - https://www.psypost.org/classic-psychedelics-linked-to-lasting-increases-in-openness-and-drops-in-neuroticism/?preview=true